At AEON, we believe skincare should be transparent, measurable, and scientifically grounded.
Below, we answer the most common questions about our delivery technologies and active molecules — how they work, why they’re different, and what makes them essential to skin longevity.

1. Transfersome Delivery

Q: What are transfersomes?
Transfersomes are ultra-deformable lipid vesicles that mimic the skin’s natural membrane structure.
Built from phosphatidylcholine, cholesterol, and edge activators like Tween-80, they can change shape to pass between skin cells and deliver actives into deeper layers — the viable epidermis and upper dermis — without disrupting the barrier.
In short, they’re microscopic shuttles that carry potent ingredients directly to the cells that matter.

Q: How do transfersomes differ from liposomes?
Traditional liposomes are rigid and tend to stay on the surface.
Transfersomes are flexible and hydro-responsive, meaning they move along the skin’s natural hydration gradient to travel further into living tissue.
They offer 5–15× greater active deposition compared to conventional emulsions or liposomes.

Q: Why does AEON use transfersome delivery?
Because it allows us to use lower concentrations of actives with higher biological impact — reducing irritation while enhancing penetration.
It also helps stabilize sensitive ingredients like retinal by shielding them inside lipid membranes until release.

2. Dissolving Microneedles

Q: What are dissolving microneedles?
They’re tiny, biodegradable micro-structures — about 500 µm long — made from biocompatible polymers such as PVA and PVP.
When applied to the skin, they painlessly dissolve, creating micro-channels that allow actives to reach the dermis with surgical precision but zero downtime.

Q: Do dissolving microneedles hurt?
No. The tips are thinner than a human hair and designed to reach below the surface nerve layer, so most people feel only light pressure.

Q: How do microneedles work with transfersomes?
Together, they form a dual-delivery system.
Microneedles create temporary pathways; transfersomes follow those channels and spread laterally, amplifying dermal diffusion and bioavailability.

3. Encapsulated Retinal

Q: What is retinal, and how is it different from retinol?
Retinal (retinaldehyde) is a direct precursor to retinoic acid, the biologically active form of vitamin A.
It works faster than retinol but with far less irritation.
In AEON formulations, retinal is encapsulated in transfersomes or HP-β-cyclodextrin to prevent oxidation and control release — giving you the benefits of prescription-level activity with the comfort of a cosmetic.

Q: Why encapsulate retinal instead of using it free?
Free retinal is unstable in light and oxygen. Encapsulation protects it, ensures steady diffusion, and dramatically extends its shelf life.

4. Peptides — Matrixyl Synthe’6™, Matrixyl 3000™, and Argireline®

Q: What’s the difference between Matrixyl Synthe’6 and Matrixyl 3000?
Both are peptide complexes developed to stimulate collagen production, but they act through different mechanisms:

• Matrixyl 3000 combines pal-GHK and pal-GQPR, signaling fibroblasts to produce collagen I and IV.

• Matrixyl Synthe’6 (pal-KTTKS) specifically targets collagen I, III, IV, laminin-5, and fibronectin, supporting the architecture of the dermal matrix.
  In simple terms: 3000 improves density; Synthe’6 refines structure.

Q: How does Argireline® fit in?
Argireline® (acetyl-hexapeptide-8) acts differently — it targets the SNAP-25 protein involved in muscle contraction, softening expression lines.
It’s often called a “topical peptide relaxer.”
In AEON formulations, we use it alongside Matrixyl peptides to address both mechanical and structural aging.

5. Adenosine

Q: What does adenosine do in skincare?
Adenosine is a naturally occurring molecule in your body’s ATP energy cycle.
Topically, it signals fibroblasts to produce collagen and elastin while reducing inflammatory markers.
It also activates A₂A receptors, improving wound healing and dermal smoothness.

Q: Is adenosine effective even though it’s water-soluble?
Normally, adenosine struggles to penetrate the lipid barrier.
In AEON formulas, it’s delivered via transfersomes or microneedle channels, ensuring it reaches its biological target — not just the surface.

6. The Bigger Picture

Q: Why combine all of these technologies?
Because true longevity skincare isn’t about single hero ingredients — it’s about systems design.
Transfersomes enhance permeability; microneedles create access; peptides rebuild structure; adenosine modulates energy; retinal reprograms renewal.
Together, they form a closed biological loop — restore, signal, and sustain.

Q: What makes AEON different from other skincare brands?
AEON applies the same computational and molecular methods used in drug discovery to everyday skincare.
We design actives through machine learning models, validate their biophysics, and deliver them through biomimetic hardware like transfersomes and microneedles — making biotech beauty accessible to everyone.